Endocrine Abstracts

Background: Non-functioning pituitary tumours can be associated with a modestly elevated prolactin. Response to dopamine agonist therapy in such cases is unusual. Large macroprolactinomas are associated with much higher prolactin levels and respond well to dopamine agonists.Case: We report a 41-year-old man with a pituitary macroadenoma associated with an elevated prolactin of around 2000mIU/l who developed marked resolution in his pituitary MRI images r...

We report a case who presented with severe symptomatic hypocalcaemia secondary to Hypomagnesaemic Hypoparathyroidism associated with use of PPI. A fifty-seven years male smoker presented with pins and needles in arms and legs for two months with intermittent attacks of his hand becoming locked and stiff (carpopedal spasm) and calf spasms. He was on long term Omeprazole for Barrett’s oesophagus. He had positive Chvostek’s and Trousseau’s sign. Investigations reve...

Objective: To highlight that an occasional case of parathyroidectomy may be followed by protracted symptomatic hypocalcaemia requiring calcium infusion and high doses of vitamin D.Case: We report a 61 years male who presented with hypercalcaemia and brown tumour. He was diagnosed as a case of primary hyperparathyroidism. He had normal FBC, U&Es, LFT, TFT and negative Endomysial antibody. Just 4 days post-parathyroidectomy he was admitted with symptom...

Objective: Factitious hypoglycaemia presents diagnostic difficulties. We report a case presenting with hypoglycaemia, due to use of herbal remedies for enhancement of sexual performance.Case: A 73-year-old male known to have peptic ulcer admitted with feeling dizzy and unwell, with blood glucose of 1.6 needed 10% dextrose infusion in the first 48 h of admission. Medications folic acid, adcal d3, omeprazole 20 mg, herbal medicine for improving sexual func...

Introduction: In spite of great progress in Endocrinology, even today Klinefelter’s syndrome remains an under diagnosed or late diagnosed chromosomal disorder as is evident from the three case reports below.Case 1: A 79 years old man admitted with exacerbation of COPD, was noted to have bilateral Gynaecomastia, feminine features, very small scrotum without testes and a small penis. Throughout his life he remained isolated and single. Scrotal ultraso...

Objective: We highlight a case of lung cancer presenting with a combination of Ectopic ACTH, SIADH and Nephrotic syndrome where paraneoplastic manifestations are the only presentation of an underlying lung cancer.Case report: Seventy year male, ex- smoker, hypertensive on Amlodipine, Irbesartan. Presented with 5-week history of leg swelling, reduced appetite.Examination showed pitting edema of the legs but no signs of cardiac, live...

Objective: The aim of this article is to acknowledge coexistence of primary hyperparathyroidism, Cushing’s syndrome in a patient with previous history thyrotoxicosis treated with radioiodine. The presentation may be another variant of multiple endocrinal neoplasias.Is there a role of previous radioiodine therapy?Case report: A 67-year-old lady with past history of thyrotoxicosis treated with radioiodine. Now hypothyroid on thy...

Objective: We present a case of primary hyperparathyroidism awaiting surgery that has probable spontaneous resolution lasting only 4 months, supposedly because of asymptomatic infarction or haemorrhage. Her PTH has risen again though her Ca is still normal. Two such cases have been described in the literature.Case report: A 74-year-old ex-smoker, hypertensive female was admitted with two days history of confusion, lethargy and feeling unwell.<p class...